INS and fetal growth restriction: This age‐related progression of changes has also been observed in IUGR/LBW offspring of different species by other researchers.[12, 67, 68] For instance, insulin sensitivity increased in LBW children at the age of two but transitioned to IR at the age of four;[12] and IUGR enhanced insulin sensitivity in IUGR piglets at 49 days of age but resulted in the opposite outcome at 105 days of age.[67] These data suggested that the age‐related transition in glucose metabolic homeostasis and insulin sensitivity may be a common feature in IUGR offspring.