Insulin resistance (IR) is defined physiologically as a state of decreased reactivity or sensitivity of insulin target tissues to high insulin levels and is considered a pathogenic driving factor for various metabolic disorders, including type two diabetes, non‐alcoholic fatty liver disease (NAFLD), and metabolic syndrome.[1, 2] Over the past few decades, the incidence of IR and related diabetes has been steadily increasing. The gene discussed is INS; the disease is metabolic syndrome.