The characteristic of this model is the presence of high levels of glucocorticoids in the mother, leading to excessive exposure of the fetus to glucocorticoids, which has also been confirmed in previous studies.[38, 59] Under this model, we elucidated the changes in insulin sensitivity of IUGR female offspring before and after birth, and demonstrated that this was associated with intrauterine exposure to high corticosteroid levels. This evidence concerns the gene INS and fetal growth restriction.