Meta-analysis was performed using a random-effects model, reporting standard mean differences (SMD) for inflammatory markers and mean differences (MD) for microbiome data, with 95% confidence intervals (CI).<h4>Results</h4>The results showed significantly elevated pro-inflammatory markers in individuals with IBS, including Interleukin (IL)-6 (SMD =  - 2.64), Tumor Necrosis Factor (TNF)-α (SMD =  - 1.97), platelet-to-lymphocyte ratio (PLR, SMD =  - 0.98), and fecal calprotectin (FC, SMD =  - 0.42), while IL-10 was lower (SMD = 2.00). This evidence concerns the gene IL6 and irritable bowel syndrome.