Several were most upregulated in specific subsets, such as multi-cytokine in CD8 memory; TIMD4/TIM3 in CD8 CM and γδT; CTLA4/CD38 in Treg, CD4 memory and CD8 CM (Fig. 4f); and OX40/EBI3 in tumor-infiltrating T cells (Supplementary Fig. 7d). This evidence concerns the gene TIMD4 and neoplasm.