Specifically, the rheumatoid arthritis dataset contributed a T peripheral helper (TPH) GEP, previously identified in inflamed synovium21 (markers included PD-1 protein, LAG3 and CXCL13 RNA; Supplementary Table 2), while the pan-cancer dataset contributed an exhaustion GEP (HAVCR2, ENTPD1, LAG3) and a T follicular helper (TFH) GEP (PD-1 protein, CXCR5 and CXCL13 RNA) distinct from a second TFH GEP discovered in the non-cancer tissue datasets. This evidence concerns the gene LAG3 and rheumatoid arthritis.