CDKL5 and craniodiaphyseal dysplasia: These models mimic some clinical CDD manifestations [[9], [10], [11],14,15], including severe learning and memory impairments, autistic-like behaviors, motor stereotypies, and visual impairment; however, spontaneous seizures were not reported in these independently generated constitutive Cdkl5 KO mice [[9], [10], [11]].