MAPT and frontotemporal dementia: Namely, mutations in tau that can promote aggregation lead to familial forms of frontotemporal dementia (FTD) and corresponding transgenic mouse models reflect aspects of disease.2 Additionally, delivery of patient derived seeding-competent tau in mouse models recapitulates neurotoxicity observed in tauopathies and the reduction of tau in mouse models of disease is neuroprotective.3,4