Tau inclusions are the defining hallmark of a family of neurodegenerative diseases termed tauopathies.1 Tau can adopt numerous disease-linked conformations that form fibrillar aggregates and possess prion-like characteristics facilitating self-propagation and spread from cell to cell via seeding.2 Importantly, the formation of pathogenic tau species has been causally linked to disease. The gene discussed is MAPT; the disease is neurodegenerative disease.