Similar to macrophages, neutrophils within tumors can be divided between anti-tumor N1 neutrophils (CD66b+ CD11b+ CD170low) that restrain tumor growth at early stages of the disease and pro-tumor N2 neutrophils (CD66b+ CD11b+ CD170high PDL1+) that tend to promote tumor growth and metastasis [15]. The gene discussed is CEACAM8; the disease is neoplasm.