While some studies assessed multiple metabolic genes in ccRCC [6,16], the prognostic role and a possible connection to the metabolic microenvironment of selected lipid metabolic sub-pathways including fatty acid degradation (FAD), fatty acid synthesis (FAS) and cholesteryl biosynthesis (Chol) has not been studied in detail to date. The gene discussed is FAS; the disease is nonpapillary renal cell carcinoma.