In addition, the application of targeted Piezo1 microbubbles combined with ultrasound, this type of approach utilizes specifically designed microbubbles, which, when combined with low-frequency ultrasound, are able to activate the mechanosensitive ion channel Piezo1 on the surface of cancer cells, leading to an increase in calcium in-flow, which in turn promotes apoptosis of the cancer cells (Fig. 3d). This evidence concerns the gene PIEZO1 and cancer.