On average, the onset of cardiac disease in genetic DCM is around 40 years, with MYH7, DSP, BAG3, RBM20, and LMNA presenting at a younger age and PLN, FLNC, and TTN at an older age (Table 3).19,21–25,27–29,43,45,59,61 However, for MYH7, it is common that DCM might appear before the age of 12 years.24 There are certain genotypes such as TTN where screening intervals could probably be safely extended to 3–5 years in relatives younger than 40 years, who do not exhibit abnormalities in ECG and cardiac imaging tests. This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.