We found 1803 significantly down-regulated and 1468 significantly up-regulated genes [log2(fold change) > 0.585 or <−0.585 (corresponding to a 1.5-fold change), false discovery rate (FDR) < 1%] that were common to the three T-DARPins (Fig. 4A and data S2), demonstrating that TBXT has widespread transcriptional properties in chordoma cells. This evidence concerns the gene TBXT and chordoma.