PRNP and prion disease: Thorough neuropathological review and immunohistochemical staining with a different anti-PrP antibody (12F10) uncovered a single occipital cortical focus and a few thalamic foci with some “typical” neuropathological features of prion disease (vacuolation, gliosis, cortical neuronal loss) including PrP immunoreactivity (Figure 4A, B, D and E).