In addition, heterogeneous nuclear ribonucleoproteins (hnRNPs) are all upregulated in READ tissues, and immunohistochemistry has confirmed the overexpressed levels of hnRNPA1, hnRNPA2B1, hnRNPK, hnRNPC, hnRNPR, and hnRNPU in READ (Li et al., 2022). The gene discussed is HNRNPA2B1; the disease is reading.