Additionally, sex hormone–mediated regulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor signaling may amplify stress-induced inflammatory responses in males during tumorigenesis (Mirili et al., 2019), as exemplified by the superior diagnostic value of combined NLR/PLR in male early gastric cancer patients (Ahn et al., 2019). The gene discussed is NR3C1; the disease is gastric cancer.