MRGPRX2 is an important target for mediating the pathogenesis of a variety of diseases, including atopic dermatitis (Jia et al. 2024), chronic spontaneous urticaria (Fujisawa et al. 2014), pseudoallergic reactions (McNeil et al. 2015), hypersensitivity‐type inflammation (Green et al. 2019), and rosacea (Muto et al. 2014). This evidence concerns the gene MRGPRX2 and atopic eczema.