MRGPRX2 is an important target for mediating the pathogenesis of a variety of diseases, including atopic dermatitis (Jia et al. 2024), chronic spontaneous urticaria (Fujisawa et al. 2014), pseudoallergic reactions (McNeil et al. 2015), hypersensitivity‐type inflammation (Green et al. 2019), and rosacea (Muto et al. 2014). Here, MRGPRX2 is linked to chronic idiopathic urticaria.