Additionally, in autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological disorder, a large (∼660 kb) heterozygous deletion upstream of the LMNB1 promoter disrupts TAD boundaries and boundary elements, resulting in at least 3 forebrain enhancers interacting ectopically with the LMNB1 promoter. Here, LMNB1 is linked to adult-onset autosomal dominant demyelinating leukodystrophy.