In our study, we demonstrated that the activation of NLRP3 signaling mitigated the cardioprotective effects of SEV against histopathological damage, CM survival and pyroptosis, and inflammatory response in rat cardiac injury in vivo, suggesting that SEV attenuated the MI-reperfusion injury via the NLRP3-mediated pyroptosis. Here, NLRP3 is linked to myocardial infarction.