FBXW7 and pulmonary fibrosis: Recent studies suggest that enhancer of zest homolog 2 (Ezh2) may increase H3K27me3 methylation at the Fbxw7 promoter, potentially repressing Fbxw7 expression, while IL-4 could reduce Fbxw7 activity to inhibit c-Jun degradation in fibrotic environments, thereby impacting pulmonary fibrosis.