Aberrant lipid metabolic pathways influence the recruitment, differentiation, and function of key immune cell populations including tumor-associated macrophages (TAMs), regulatory T cells (Tregs),and myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), CD8+ T cells,contributing to an immunosuppressive microenvironment that facilitates tumor progression. This evidence concerns the gene CD8A and neoplasm.