HIF1A and posterior cortical atrophy: Interestingly, Reactome pathway analysis revealed that PSMA1 may be involved in HIF-1α oxygen-dependent proline hydroxylation and NF-κB signaling activation (STRING: functional protein association networks: string-db.org), which was consistent with the involvement of Neu_c09_HLA in the regulation of the HIF-1α signaling pathway (Figure 5G); these results suggested that Neu_c09_HLA may regulate hypoxia in the TIME of PCa through PSMA1.