Anti-Ro60 (SSA) and anti-Ro52 (TRIM21) antibodies target distinct ribonucleoprotein (RNP) complexes and are established biomarkers in Sjögren’s disease (SjD) and systemic lupus erythematosus (SLE) (1–3). The gene discussed is RNPC3; the disease is systemic lupus erythematosus.