Associations with renal or hepatic involvement were not significant in any antibody group (all p > 0.05).Notably, both Ro52+/Ro60+ and Ro52+/Ro60− subgroups exhibited a significantly increased likelihood of ILD, while only the Ro52+/Ro60+ group was significantly associated with hematologic abnormalities. Here, TRIM21 is linked to interstitial lung disease.