The expression of cytokines (IL-1, IL-6, IL-8, IL-15, IL-17, IL-33, TNF-α, IFN-γ), thrombospondin-1, chemokines (CXCL12, CXCL8, CCL20), etc. can be increased, leading to the aggregation of inflammatory cells, further exacerbating the synovial inflammation and other pathological reactions of RA. Here, IL1B is linked to rheumatoid arthritis.