In addition, under the hypoxic microenvironment of RA, HIF-1α not only promotes the polarization of B cells to the IL-6 phenotype, enhances the secretion of inflammatory factors, and activates the STAT3 signaling pathway, but also maintains the survival and function of IL-10-regulated B cell subsets by regulating glycolysis and co-transcriptional regulation of STAT3 (102). The gene discussed is IL6; the disease is rheumatoid arthritis.