Further studies have shown that under hypoxic conditions, up-regulation of HIF-1α leads to an increase in glucose transporter GLUT1 and GLUT3 in RA synovial tissue, thereby promoting glucose uptake and further enhancing the process of glycolysis by regulating the activities of hexokinase II, glyceraldehyde 3-phosphate dehydrogenase and mitochondrial cytochrome oxidase (126, 127). The gene discussed is HIF1A; the disease is rheumatoid arthritis.