Yamamoto M et al. reported that HE4 was indirectly involved in cardiac fibrosis by activating cardiac fibroblasts (16), LeBleu et al. reported that HE4 could be involved in renal fibrosis by inhibiting the activities of serine proteases and matrix metalloproteinases and is correlated with the severity of renal fibrosis (17). This evidence concerns the gene WFDC2 and renal fibrosis.