These results suggest that Talh honey may attenuate obesity and related metabolic disturbances through mechanisms that enhance peripheral insulin sensitivity—potentially by upregulating GLUT-4 expression and promoting glucose uptake in muscle and adipose tissues, while simultaneously suppressing hepatic and adipose lipogenesis and reducing serum free fatty acid levels. The gene discussed is SLC2A4; the disease is obesity due to melanocortin 4 receptor deficiency.