The underlying mechanism in the regulation of neuronal activity on KCC2 surface expression is through KCC2 phospho-regulation, which is crucial for modulating its function; dysregulation of KCC2 phosphorylation mediates the development and severity of epileptic seizures (Chamma et al., 2013; Silayeva et al., 2015; Pisella et al., 2019; Friedel et al., 2015; Kahle et al., 2013). The gene discussed is SLC12A5; the disease is Seizure.