SLC12A5 and Global developmental delay: Human patients with mutations in the SLC12A5 gene develop severe epilepsy soon after birth and developmental delay, while deletion of the SLC12A5 gene in mice causes hyperexcitability in the hippocampus, generalized seizures, temporal lobe epilepsy, and death shortly after birth (Kelley et al., 2018; Chen et al., 2017; Uvarov et al., 2007; Woo et al., 2002; Hubner et al., 2001; Stodberg et al., 2015; Saitsu et al., 2016; Saito et al., 2017).