TP53 and hepatocellular carcinoma: Exploring the clinicopathological and biological underpinnings of the HCCEvoSig signature using the TCGA-LIHC cohort, we found that HCC tumors with high HCCEvoSig scores exhibited elevated activity in cell cycle-related pathways (Figure 5A; Supplementary Table S20), such as DNA replication, cell cycle, and p53 signaling pathway, along with enhanced central carbon metabolism.