Additionally, we investigated whether the core genes of HCCEvoSig were included in the CancerLivER database (Kaur et al., 2020), which comprises over 594 liver cancer biomarkers, and found that four of 11 genes (ADH4, CYP2C9, SPP1 and SERPINE1) were included in the database. The gene discussed is ADH4; the disease is liver cancer.