Importantly, while APOE4 carriers exhibited an increased AD risk regardless of menopause age, stratification by menopause age revealed that APOE4 carriers with early menopausal age had the highest AD risk (OR:6.32, 95% CI: 4.78–8.34, p-value < 0.001), followed by APOE4 carriers with normal menopause age (OR:4.85, 95% CI: 4.0–5.9, p-value < 0.001), followed by APOE4 non-carriers with early menopause age (OR:1.56, 95% CI: 1.1–2.2, p-value = 0.008) (Figure 7D), relative to E4 non-carriers with normal menopause age. The gene discussed is APOE; the disease is Alzheimer disease.