APOE and Alzheimer disease: The greatest risk factors for Alzheimer′s disease (AD) are age, APOE4 allele, and female sex (Altmann et al., 2014, Farrer et al., 1995, Hebert et al., 2013, Sala Frigerio et al., 2019, Payami et al., 1996, Barnes et al., 2005, Nebel et al., 2018).