After the onset of cerebral ischemia, dead cells and macrophages actively secrete DAMPs (damage-associated molecular patterns) (Gong et al., 2020), which include high mobility group box 1 (HMGB1), s100, and ATP, and play a role in initiating immune responses after central nervous system injury (An et al., 2014). The gene discussed is HMGB1; the disease is Cerebral ischemia.