SPP1 and osteoporosis: demonstrated that both vibration therapy alone and herbal medicine independently prevented osteoporosis in ovariectomized rats, 50 ovariectomized rats were divided into five groups and after 12 weeks of treatment, levels of osteopontin (OPN), RANKL and bone turnover markers in serum were measured, and bone density (BMD), histomorphometry and bone strength were evaluated, their combination significantly enhanced bone mineral density (BMD), bone strength, and bone structure, thereby amplifying the therapeutic effects of vibration therapy (32).