They found that metformin can not only significantly improve 17-hydroxylase expression in ovarian structures, reduce body weight, increase glucose and insulin levels in PCOS rats, but also promote the proliferation of sphincteric interstitial and mesenchymal cells and improve angiogenesis, which consequently promotes follicular development and ovulation (Mahamed et al., 2018). The gene discussed is INS; the disease is polycystic ovary syndrome.