Metformin treatment not only significantly improves metabolic and endocrine markers in patients with PCOS but also achieves a reduction of more than 10% in parameters such as weight, serum alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) levels (de Oliveira et al., 2019; Ruan et al., 2023; Guan et al., 2020; Riemann et al., 2022). The gene discussed is GPT; the disease is polycystic ovary syndrome.