TGFB1 and neoplasm: M2 (alternatively activated, protumorigenic) macrophages are polarized by CSF‐1, IL‐4, IL‐10, IL‐13, and so on, leading to the secretion of IL‐10 and TGF‐β, the induction of Treg cells, and the promotion of tumor cell growth, migration, and metastasis, thus creating an immunosuppressive microenvironment [189].