SQSTM1 and non-small cell lung carcinoma: Pharmacological activation of GABA-A receptors has been shown to induce autophagy by activating the GABA-A receptor-associated protein (GABARAP), the mitochondrial receptor NIX and utilizing the ubiquitin-binding protein p62, which inhibits the proliferation of non-small cell lung cancer (NSCLC) cells and brain metastases while reducing the toxicity of radiotherapy (69).