verified that in the NSCLC cell lines A549 and SPC-A-1, the expression of the autophagy marker sequestosome 1 (SQSTM1, abbreviated P62) was positively correlated with PD-L1 expression (30), p62 interacts with ubiquitinated proteins and subsequently associates with microtubule-associated protein 1 light chain 3 beta-II (LC3-II) localized on the autophagosomal membrane to promote autophagy (31). The gene discussed is CD274; the disease is non-small cell lung carcinoma.