In another study, using in vitro and injection-induced tumor models of B16F10 melanoma, Py8119 triple-negative breast cancer, and MC38 colon carcinoma, researchers also found that the inactivation of autophagy associated protein 5 (Atg5) makes MHC-I-deficient tumor cells more susceptible to T cell-mediated cytokine-induced apoptosis (29). This evidence concerns the gene ATG5 and neoplasm.