Second, in specific cellular components of the TIME, the regulation of immune function by DDIT4-mediated inhibition of the PI3K-Akt/mTOR pathway is a combined effect of multiple mechanisms (e.g., changes in metabolic state and autophagy activation); and whether to promote anti-tumor immunity or facilitate tumor immune evasion, there are varying changes among different cell types. The gene discussed is DDIT4; the disease is neoplasm.