Conversely, in a more recent study, researchers found that andrographolide (AD) induces autophagy, leading to increased CD8+ T cell infiltration in tumor tissues of AD-treated mice in both H1975 human NSCLC xenograft and Lewis lung carcinoma models; this effect was attributed to the more pronounced autophagic activity in tumor cells, where accelerated PD-L1 degradation alleviated the suppression of CD8+ T cells (64). The gene discussed is CD8A; the disease is Alzheimer disease.