It also showed superior improvements in serum tumor markers: cancer antigen 125 (CA125) [mean difference (MD) = −1.69, 95% CI [−2.73, −0.65], p < 0.001, I2 = 83%], Carbohydrate antigen 19-9 (CA199) (MD = −2.12, 95% CI [−3.39, −0.84], p = 0.001, I2 = 85%), and carcinoembryonic antigen (CEA) (MD = −2.01, 95% CI [−2.53, −1.50], p < 0.001, I2 = 99%), although Squamous Cell Carcinoma Antigen (SCC) improvement was non-significant (MD = −1.19, 95% CI [−2.61, 0.24], p > 0.001, I2 = 100%). The gene discussed is CEACAM5; the disease is neoplasm.