Regarding safety, albumin-bound paclitaxel had markedly lower incidences of diarrhea (RR = 0.49, 95% CI [0.33, 0.72], p = 0.003, I2 = 0%), nausea/vomiting (RR = 0.61, 95% CI [0.46, 0.80], p < 0.001, I2 = 0%), thrombocytopenia (RR = 0.61, 95% CI [0.44, 0.85], p = 0.004, I2 = 22%), and myalgia/arthralgia (RR = 0.45, 95% CI [0.22, 0.94], p = 0.03, I2 = 0%), while neutropenia showed no significant difference (RR = 0.58, 95% CI [0.32, 1.03], p = 0.006, I2 = 0%). This evidence concerns the gene ALB and Decreased total neutrophil count.