More recently, attention has shifted toward their anti-inflammatory and immunomodulatory effects, including downregulation of NF-κB pathways, suppression of IL-6 and TNF-α, and enhancement of regulatory T-cell responses.2,3 These mechanisms warrant exploration of GLP-1 analogues in autoimmune conditions, including Sjögren’s syndrome. The gene discussed is GLP1R; the disease is Autoimmunity.