Such studies will help us to better define their (miR-330-5p/ADAM17-induced signalling) role in systemic vs. localized responses to infection; (ii) the selective viral invasion of the midbrain reported in our study as SARS-CoV-2 could only invade midbrain of only two out of seven mice; and (iii) the effect on astrocyte function, vascular damage and disruption of the blood–brain barrier. This evidence concerns the gene ADAM17 and infection.