We examined the association of the PRS-RCDII, derived from three non-HLA genetic variants, namely rs2041570 on chromosome 7p14.3 (FAM188B), rs7324708 on chromosome 13q22.1 (KLF12), and rs205047 on chromosome 17p12 (SHISA6), with 27 unique phecodes related to autoimmune diseases. This evidence concerns the gene KLF12 and autoimmune disease.