It also influences the adipogenic differentiation of bone marrow and adipose tissue, mediating the transcriptional activity of PPARy.(63) Finally, NCOA1 is responsible for mediating lipolysis in differentiated adipocytes so that tumor cells can capture the released fatty acids and produce energy for their proliferation via autocrine mechanisms.(64,65) Thus, we postulated these coactivators influence prostate cancer by stimulating adipogenesis, de novo lipogenesis, and cholesterogenesis, just as the lipid environment favors the presence of coactivators that trigger disease progression. Here, NCOA1 is linked to Familial prostate cancer.