Univariate regression analysis showed that HADS scores (Anxiety and Depression), SF-36v2 acute scores (General health perception, Vitality, Social functioning, and Mental health), risk-reducing mastectomy, risk-reducing salpingo-oophorectomy, and the status of BRCA1/2 variant carriers were significantly associated with the MICRA-J Total score (Table 5). This evidence concerns the gene BRCA1 and major depressive disorder.