10,14 These mutations alter leukocyte behaviour, promoting a pro-inflammatory and metabolically active macrophage phenotype, which has been implicated in accelerated atherogenesis.8,15–21 Experimental data suggest that CHIP-mutated macrophages exhibit increased inflammasome activation, cytokine secretion, and metabolic perturbation, leading to plaque progression and instability—key determinants of CAD severity and mortality.22 The gene discussed is STUB1; the disease is coronary artery disorder.