DNM1L and microcephaly: Indeed, point mutations in human Drp1 cause encephalopathy due to defective mitochondrial and peroxisomal fission-1, a devastating disorder that presents with microcephaly, developmental delay, refractory epilepsy, or lethal infantile encephalopathy (Fahrner et al., 2016; Lhuissier et al., 2022; Liu et al., 2021; Vanstone et al., 2016).