A higher arteriosclerosis burden correlated with higher plasma marker concentrations, especially for NfL (e.g., βintracranial carotid: 0.15, [95% Confidence interval (CI): 0.04, 0.26]) and Aβ40 (e.g., βintracranial carotid: 0.18, [95% CI: 0.05, 0.30]). The gene discussed is NEFL; the disease is arteriosclerosis.