In the context of mammalian virus infection, the SRR1 domain-containing gene SRRD has appeared as a pro-viral hit in previously performed CRISPR/Cas9 screens in Huh7.5.1, human cells, with hepatitis C virus (23) and Vero E6, African green monkey cells, with SARS-CoV-2 (24, 25). The gene discussed is SRRD; the disease is viral infectious disease.