In the context of virus infection, mammalian cell culture CRISPR/Cas9 screens have uncovered SRRD as a pro-viral host factor for hepatitis C virus (23) and SARS-CoV-2 (24, 25) infection, although the biochemical mechanism of SRRD in virus infection is currently unknown, and detailed characterization of SRRD is lacking. The gene discussed is SRRD; the disease is viral infectious disease.