Gut microbe engineering is a promising tool for the treatment of chronic diseases.112 Genetically engineered Lactobacillus expressing angiotensin converting enzyme (ACE) 2 has been shown to lower blood pressure in female Ace2 knockout rats, linked to a specific reduction in colonic AngII, but not renal AngII.50 Indeed, this engineered ACE2 expressing Lactobacillus strain has been shown to restore the intestinal expression ACE2, resulting in a preservation of gut barrier integrity.113 These studies prove the feasibility of targeting the intestine to mitigate high blood pressure. The gene discussed is ACE2; the disease is hypertensive disorder.