AGT and hypertensive disorder: 52 Studies on the colonic organoids and isolated epithelium demonstrated that the expression of most genes involved in the antigen presentation pathway was significantly downregulated in the SHR compared to WKY, resulting in ineffective immune responses to gut dysbiosis and the altered luminal environment in HTN.93,95 In another model, exposure to a high-salt diet after administering Ang II resulted in an accumulation of macrophages and lymphocytes in the kidney, subsequently elevating blood pressure levels.96