Butyrate was able to rescue the deficits in mitochondrial respiration and prevent it from undergoing autophagy.110 In HTN, SCFA butyrate improved gut pathology and barrier function, and suppressed AngII-induced HTN.58 Using the colonic organoids derived from SHRs and subjects with high blood pressure.95,111 butyrate was found to upregulate the expression of TJ proteins, suggesting a direct effect of butyrate on the gut epithelium. The gene discussed is AGT; the disease is hypertensive disorder.