Additionally, the connective tissue growth factor (CTGF/CCN2) has been found to be highly expressed in both epithelial and connective tissues in gingival fibromatosis lesions, suggesting that epithelial-mesenchymal interactions may promote gingival fibrosis,97 which could serve as another target for molecular-based therapies. Here, CCN2 is linked to hereditary gingival fibromatosis.