RELN and early-onset autosomal dominant Alzheimer disease: Notably, reduced Reelin signaling has been observed in patients with neurodevelopmental and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease (Folsom and Fatemi 2013; Katsuyama and Hattori 2024; Krstic et al. 2013; Cuchillo‐Ibañez et al. 2016; Faini et al. 2021; Reive et al. 2024).