The conducted analysis showed that the risk factors influencing the change of transcriptional activity of the studied genes include: a history of myocardial infarction (TGF‐β1 and TGF‐β1R III), negative family history (TGF‐β1 and TGF‐β1 RI, TGF‐ β1 RII, TGF‐β1 RIII), overweight/obesity (TGF‐β1 and TGF‐β1 RIII), hypertension (TGF‐β1 and TGF‐β1 RIII), atherosclerosis (TGF‐β1 RI, TGF‐β1 RII, TGF‐β1 RIII), diabetes and lipid disorders (TGF‐β1 RIII). This evidence concerns the gene TGFB1 and atherosclerosis.