TGFB1 and obesity due to melanocortin 4 receptor deficiency: The conducted analysis showed that the risk factors influencing the change of transcriptional activity of the studied genes include: a history of myocardial infarction (TGF‐β1 and TGF‐β1R III), negative family history (TGF‐β1 and TGF‐β1 RI, TGF‐ β1 RII, TGF‐β1 RIII), overweight/obesity (TGF‐β1 and TGF‐β1 RIII), hypertension (TGF‐β1 and TGF‐β1 RIII), atherosclerosis (TGF‐β1 RI, TGF‐β1 RII, TGF‐β1 RIII), diabetes and lipid disorders (TGF‐β1 RIII).