PTPRZ1 and neoplasm: Leveraging an integrative multi‐omics framework—spanning ChIP‐seq, bulk RNA‐seq, single‐cell ATAC/RNA‐seq, and spatial transcriptomics—we identified PTPRZ1 as a previously unrecognized SOE‐driven oncogene. PTPRZ1 exhibited robust tumor‐specific expression, with functional assays demonstrating its critical role in accelerating cellular proliferation and migration in vitro.