SOX2 and head and neck squamous cell carcinoma: Notably, LUSC shares essential transcriptional regulators—including SOX2, p63, KLF5, and GRHL2—with other SCCs, such as esophageal squamous cell carcinoma (ESCC) and head and neck squamous cell carcinoma (HNSCC).[19] These transcription factors play a pivotal role in orchestrating enhancer‐driven oncogenic programs, thereby modulating critical signaling pathways, including NFκB and the epithelial‐mesenchymal transition, both of which are vital in the pathogenesis of SCCs.