Previous studies have shown that targeting super‐enhancer (SE)‐linked oncogenes could lead to significant tumor regression with potential applications in cancer therapy.[40] In line, we found that there were three SOEs adjacent to PTPRZ1 in the gene desert region, containing a total of nine cis‐regulatory elements (CREs), which were reported by the Encyclopedia of DNA Elements (ENCODE) Project.[41] These SOEs were highly enriched for both H3K27ac signals and binding of the 4 abovementioned master TFs (Figure 3A). The gene discussed is PTPRZ1; the disease is neoplasm.