RORB transcriptionally activates its target genes, nuclear receptor subfamily 1 group D member 1 (NR1D1) and RIO kinase 3 (RIOK3), in a circadian clock‐dependent manner, leading to attenuated activation of nuclear factor kappa B (NF‐κB) signaling, subsequent de‐repression of folliculin (FLCN) and folliculin interacting protein 1 (FNIP1) levels, and decrease of lysosomal biogenesis in NB. Here, RIOK3 is linked to neuroblastoma.