Previous studies indicate that diploidy is associated with early treatment failure of NB patients, whereas individuals with hyperdiploidy (predominantly near‐triploid) exhibit long‐term survival.[30] In diploid and tetraploid NB specimens, higher frequencies of structural chromosome aberrations and MYCN amplification are noted than those of near‐triploid tumors.[31] However, due to limited case number, the association of RORB expression with NB cell ploidy warrants further investigation. The gene discussed is RORB; the disease is neuroblastoma.