SMAD2 and non-small cell lung carcinoma: Integrin αvβ6 was also shown to stimulate cancer metastasis, which was partly from the upregulation of interleukin‐8‐mediated signaling.[45] In our study, we performed immunohistochemistry of multiple proteins (TGFβ1, Smad2, fibronectin, vimentin, MMP9, and Ki‐67) in tumor samples to explore the possible mechanism of integrin αvβ6 in NSCLC.