TGFB1 and cancer: Integrin αvβ6 has multiple pro‐tumorigenic effects, with roles in several different signaling pathways and functions in accelerating tumor progression.[43] For instance, integrin αvβ6 can induce the activation and release of TGFβ1 from the latent TGFβ complexes and subsequently activate TGFβ/SMAD signaling pathway to aid cancer metastasis by positively regulating the EMT process.