Integrin αvβ6 was also shown to stimulate cancer metastasis, which was partly from the upregulation of interleukin‐8‐mediated signaling.[45] In our study, we performed immunohistochemistry of multiple proteins (TGFβ1, Smad2, fibronectin, vimentin, MMP9, and Ki‐67) in tumor samples to explore the possible mechanism of integrin αvβ6 in NSCLC. This evidence concerns the gene SMAD2 and neoplasm.