2017; Sheng et al. 2019). The anti‐obesity effects of P. ostreatus (5% and 10% powder in the diet for 6 weeks) have been demonstrated in high‐fat diet (HFD)‐induced obese Crj: CD‐1 (ICR) mice. This treatment resulted in reduced body weight gain and the accumulation of subcutaneous epididymal and inguinal white adipose tissue, as well as a decrease in fasting blood glucose, improved glucose intolerance and insulin sensitivity, and a reduction in serum cholesterol, triglyceride, and low‐density lipoprotein (LDL) levels (Y. Hu et al. 2022). This evidence concerns the gene INS and Glucose intolerance.