2015). A single dose of mushrooms was administered early, followed by a glucose load. The mushrooms reduced postprandial serum glucose levels and increased serum insulin levels in T2DM patients. The hypoglycemic effects of mushrooms are attributed to multiple mechanisms, including the increase in glucokinase activity, which promotes insulin secretion and glucose utilization by peripheral tissues, and the inhibition of GSK, which promotes glycogen synthesis in the liver (Abu Aqel et al. 2024; Teli and Gajjar 2023). This evidence concerns the gene INS and type 2 diabetes mellitus.